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Natural Products for Drug Discovery: Discovery of Gramines as Novel Agents against a Plant Virus
關 鍵 字:  
文 獻 號: 152926  文獻類型: 期刊 
個人著者: Lu, Aidang;Wang, Tienan;Hui, Hao;Wei, Xiaoye;Cui, Weihao;Zhou, Chunlv;Li, Hongyan;Wang, Ziwen;Guo, Jincheng;Ma, Dejun;et al 
著者單位:  
文獻來源: 《Journal of Agricultural and Food Chemistry》,2019年  
 

摘要

Plant viral diseases seriously affect crop yield and quality. The natural product gramine (I) and its simple structural analogs were synthesized from indoles, amines, and aldehydes in one step. The antiviral effects of these alkaloids were evaluated systematically. Most of these compds. were found to have higher antiviral effects than com. ribavirin for the first time. Esp. compds. (II), (III), and (IV) exhibited significantly higher effects than ningnanmycin, thereby emerging as novel antiviral leads for further optimization. The preliminary implementation indicated that these compds. likely inhibit the assembly of tobacco mosaic virus by crosslinking TMV capsid protein. Gramine analogs were also found to have broad-spectrum fungicidal effects. Although gramine has been reported to have influence on germination and development of Erysiphe graminis, these compds. displayed no fungicidal effects against Blumeria graminis f. sp. tritici on wheat in our test. Some of these compds. also exhibited certain insecticidal activities.

 
 
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